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Pseudoexfoliation syndrome
Pseudoexfoliation syndrome (other names: ''Exfoliation glaucoma'', ''Pseudoexfoliation glaucoma'', ''Pseudoexfoliation of the lens'', ''Exfoliation syndrome''), sometimes abbreviated as PEX, is an aging–related systemic disease manifesting itself primarily in the eyes which is characterized by the accumulation of microscopic granular amyloid-like protein fibers.〔 Its cause is unknown, although there is speculation that there may be a genetic basis. It is more prevalent in women than men, and in persons past the age of seventy. Its prevalence in different human populations varies; for example, it is prevalent in Scandinavia. The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause, in turn, a buildup of pressure leading to glaucoma and loss of vision. As worldwide populations become older because of shifts in demography, PEX may become a matter of greater concern.〔
==History==
Pseudoexfoliation syndrome (PEX) was first described by an ophthalmologist from Finland named John Lindberg in 1917.〔 He built his own slit lamp to study the condition and reported "grey flakes on the lens capsule", as well as glaucoma in 50% of the eyes, and an "increasing prevalence of the condition with age."〔 Several decades later, an ocular pathologist named Georgiana Dvorak-Theobald suggested the term ''pseudo''exfoliation to distinguish it from a similar ailment which sometimes affected glassblowers called ''true exfoliation'' syndrome. The latter ailment is caused by heat or "infrared-related changes in the anterior lens capsule" and is characterized by "lamellar delamination of the lens capsule."〔 Sometimes the two terms "pseudoexfoliation" and "true exfoliation" are used interchangeably〔 but the more precise usage is to treat each case separately.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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